Plasticity of P2X Channel Function and Chronic Visceral Pain

• 作 者: Shufen Hu Youlang Zhou Jingde Tao Xinghong Jiang Guangyin Xu
• 机 构: Soochow University, China
• 出 处: The 4th International Ion Channel Conference(第四届国际离子通道会议)
• 发表日期: 2013年2期
• 关键词: P2X receptors Irritable bowel syndrome Visceral pain Hydrogen sulfide Dorsal roo

Purinergic signaling contributes significantly to cutaneous, musculoskeletal and visceral nociception and on the roles played by P2X3, P2X2/3, P2X4, P2X7 ATP receptor channels in neuropathic and inflammatory pain.Irritable bowel syndrome (IBS) is a common gastrointestinal disorder and characterized by chronic abdominal pain and bloating in association with altered bowel movements.