【摘 要】
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Exposure to the highly pathogenic influenza A virus,subtype H1N1 and/or H5N1 virus,is responsible for the considerable global pandemic threat.In the prophylaxis and treatment of influenza,neuraminidas
【机 构】
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School of Pharmacy,National Defense Medical Center,Taipei
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Exposure to the highly pathogenic influenza A virus,subtype H1N1 and/or H5N1 virus,is responsible for the considerable global pandemic threat.In the prophylaxis and treatment of influenza,neuraminidase(NA),the enzyme cleaving a terminal sialic acid(SA)residue from glycoconjugates enabling the release of the virion from infected cells,has been considered an ideal target for designing promising therapeutics.One of such potent and specific NA inhibitors is oseltamivir(Tamiflu),a transition-state analog of SA obtained by the computer-aided technique.Apart fromantiviral agents,plant phenolics,an important class of phytomedicines of interest against flu and other diseases,reveal the true impact of the treatments.
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