Astragaloside Ⅳ ameliorated mitochondrial oxidative stress in hypertensive mice with cardiomyopathy

来源 :Ready for 2018- the 4th China International Forum on Hyperte | 被引量 : 0次 | 上传用户：jiansilang2006

【摘要】

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　　Objective:Mitochondrial oxidative stress has been implicated in hypertensive cardiomyopathy.Abnormal Ca2+ handling is thought to be related with triggered a

【作者】

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QiongyingWang[1]AnXie[2]HanXu[1]JingYu[1]

【机构】

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Section of Hypertension,Lanzhou University Second Hospital of,Lanzhou,Gansu,P.R.China

【出处】

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Ready for 2018- the 4th China International Forum on Hyperte

【发表日期】

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2015年期

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　　Objective:Mitochondrial oxidative stress has been implicated in hypertensive cardiomyopathy.Abnormal Ca2+ handling is thought to be related with triggered activity and mitochondria participate in Ca2+ homeostasis.Astragaloside Ⅳ (ASI) is reported to increase the scavenging of reactive oxygen species (ROS) and nitric oxide(NO) production.We evaluated the contribution of ASI for mitochondrial ROS and Ca2+ Flux to cardiac function by using DOCA-salt hypertensive mice.

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Astragaloside Ⅳ ameliorated mitochondrial oxidative stress in hypertensive mice with cardiomyopathy

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