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Outline ·Background and Objectives · Methods ·Results ·Discussion ·Conclusions Background-Bitopertin ·Bitopertin is a glycine reuptake inhibitor that is postulated to improve NMDA receptor hypofunction by increasing the synaptic concentration of glycine, an obligatory co-agonist at the NMDA receptor ·PK property-Absorption is good but slightly less than dose proportional at doses above 50 mg due to the low solubility and incomplete absorption of the dose -Rapid and extensive distribution into tissues -In vitro and in vivo studies have shown that CYP3A4 is the major enzyme responsible for metabolism