Liposomes encapsulated iridium(Ⅲ)polypyridyl complexes for enhanced tumor suppression

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：w11122

【摘要】

：

A series of novel metal iridium complexes containing phenanthroline derivatives were designed and synthesized by changing the substituent groups on the phenanthroline derivatives [1].

【作者】

：

Miao He Wen-Yao Zhang Fan Du Yi-Ying Gu Lan Bai Zhi Jia Yun-Jun Liu

【机构】

：

School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou,510006,P.R.China

【出处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

iridium(Ⅲ) complex liposome Apoptosis

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　A series of novel metal iridium complexes containing phenanthroline derivatives were designed and synthesized by changing the substituent groups on the phenanthroline derivatives [1].

其他文献

Influence of Mitochondrion-Targeting Group on the Anticancer Activity of Copper Complexes

Mitochondria participate in multifarious cellular functions,especially in energy production and cell apoptosis.

会议

MitochondriaTriphenylphosphineCopper complexesAnticancerApoptosis

Small molecule Dysregulates Mitochondrial ClpP

The human ClpP proteolytic complex(HsClpP)is a serine protease located in the mitochondrial matrix and participates in the maintenance of mitochondrial protein quality by degrading misfolded protein [

会议

mitochondrial HsClpPallosteric agonistanti-cancer therapy

High-throughput screening for identification of selective peptide-based BRD4 inhibitors and their ap

BRDs(Bromodomains)are a class of proteins that can specifically recognize and bind to acetyllysine.

会议

BRD4peptideacetyllysinefluorescence probe

Multifunctional Gold Nanoparticles as Smart Nanovehicles with Enhanced Tumour-Targeting Abilities fo

A number of multimodal agents have been developed for tumour imaging and diagnosing,however,most of them cannot be used to study the detailed physiological or pathological changes in living cells at t

会议

pH mappingtumour-targetingfluorescence imagingMRIdual-modal agents

Small Molecule Dac51 Targeting FTO

FTO,the first m6A demethylases,has been reported to regulate tumorigenesis of glioblastoma stem cells [1] and melanoma [2].

会议

FTOinhibitortumorigenesisdruggability

金属离子调控人工金属蛋白水解活性研究

新型人工金属蛋白扩展了天然蛋白催化应用领域，在近些年引起研究者的兴趣[1]，其中在我们前期设计的人工金属蛋白中L29E Mb 蛋白表现出了较好的水解活性，并且我们以ZnPP 为金属辅基构建了系列具有光调控核酸酶活性的人工金属蛋白[2]。

会议

人工金属蛋白水解酶肌红蛋白

纳米铂(Ⅳ)-铁(Ⅲ)双金属配位聚合物用于肿瘤的化学和化学动力学联合治疗

顺铂作为一线化疗药物对多种肿瘤有治疗效果，但因其存在的毒副作用和耐药性等缺陷，严重限制了其临床应用。四价铂前药以其良好的稳定性、较好的脂溶性和较低的毒性等优势，可有效克服铂类药物的缺陷。

会议

铂类抗肿瘤药物化学动力学治疗联合治疗肿瘤微环境

斯诺普利吸入气雾剂治疗肺动脉高压的研究

肺动脉高压(Pulmonary Arterial Hypertension,PAH)是一类快速进展且病情严重的肺血管疾病,被称为“心血管中癌症”.NO 在心肺血管系统中具有舒张血管、降低血压、抑制血管平滑肌增殖、影响血管重构和血小板粘附等重要生理作用,因而在高血压、心肌缺血、肺动脉高压等心肺血管疾病的发病中具有重要意义.

会议

斯诺普利NO肺动脉高压吸入气雾剂

Novel Dibenzoxanthenes Compounds Inhibit Human Gastric Cancer SGC-7901 Cell Growth by Apoptosis

In our previous work,we have designed and synthesized a series of dibenzoxanthenes(Figure.1)which showed antitumor activity.

会议

dibenzoxanthenesgastric cancer cellsDNA bingdingapoptosiscytotoxicity

基于荧光素酶互补生物传感器的化学小分子快速检测方法的构建及应用

PCA(Protein-fragment complementation assays,蛋白质片段互补)实验结合荧光蛋白和荧光素酶等报告系统,被广泛地用于细胞内蛋白互作检测以及药物研发等.Ingrid Remy等人报道[1],将Gaussia 荧光素酶(GLuc)分成N 片段和C 片段后分别与互作蛋白融合,可以重构GLuc 对其底物CTZ(coelenterazine,腔肠素)的催化功能.

会议

GLucPCA氯霉素生物传感器

Liposomes encapsulated iridium(Ⅲ)polypyridyl complexes for enhanced tumor suppression

其他学术论文