An Associative Novel Two-Metal-Ion Mechanism for Type Ⅱ Topoisomerases Supported by QM/MM and QTCP S

来源 :第十三届全国量子化学会议 | 被引量 : 0次 | 上传用户：belive

【摘要】

：

Type Ⅱ topoisomerase catalyzes the relaxation of supercoiled DNA by transient cleavage and rejoining of both DNA helixes.However,the catalysis employing a combination of nucleobase and divalent metal

【作者】

：

Jingheng Wu Yajuan Ding Hui Chao Yong Shen

【机构】

：

School of Chemistry,Sun Yat-sen University,510275,Guangzhou,P.R.China

【出处】

：

第十三届全国量子化学会议

【发表日期】

：

2017年10期

【关键词】

：

Type Ⅱ topoisomerase DNA scission QM/MM QTCP

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An Associative Novel Two-Metal-Ion Mechanism for Type Ⅱ Topoisomerases Supported by QM/MM and QTCP S

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