• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafe

iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafe

来源 :中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：chessinge
【摘 要】
：
The combination of doxorubicin(DOX)with sorafenib(SOR)has been proved to be an effective strategy to enhance anti-hepatocellular carcinoma(HCC)efficiency [1].However,respective in vivo pharmacokinetic
【作 者】
：
Jinming Zhang Jie Hu Melissa Skibba Guang Liang Yitao Wang Meiwan Chen 
【机 构】
：
State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,U
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
【发表日期】
：
2014年6期
【关键词】
：
Hepatocellular carcinoma Active targeting Doxorubicin Sorafenib iRGD peptide 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　The combination of doxorubicin(DOX)with sorafenib(SOR)has been proved to be an effective strategy to enhance anti-hepatocellular carcinoma(HCC)efficiency [1].However,respective in vivo pharmacokinetic profiles and different endocytosis capacities of these two drugs greatly hinder their current application [2].To solve these problems and enhance the anti-HCC efficacy,the tumor-targeting poly(lactic-co-glycolic acid)(PLGA)-lecithin-poly(ethylene glycol)(PEG)core-shell nanoparticles(NPs)decorated with a tumor-penetrating peptide iRGD were developed for DOX and SOR co-delivery.
其他文献
Enhanced Restraining Circulating Colorectal Cancer Cells in Blood and Their Hetero-Adhesion to Endot
Dissemination of circulating tumour cells (CTCs) to potential metastatic sites mostly occurs in the circulation system.CTCs in blood and their hetero-adhesion to vascular endothelial bed of distant me
会议
Recognition and Down-Regulation of Circulating Tumor Cells by Dual-Aptamer-Coated Mesoporous Silica
The main reason for most cancer deaths is tumor metastasis.Circulating tumor cells (CTCs) are thought to be responsible for metastasis,so the capturing and restraining of CTCs may serve as an efficien
会议
New molecular beacon for detection of p53 gene point mutation and its potential as a primer for poly
Due to the relatively mature technologies to manipulate nucleic acids at will and the intrinsic properties of these biomacromolecules,oligonucleotides are widely explored as detection probes to develo
会议
Nanoparticle-assisted combination therapy against triple negative breast cancer by using miR-34a and
Metastatic relapse,development of drug resistance in cancer cells and adverse side effects of chemotherapeutic agents are the major obstacles for effective chemotherapy against triple-negative breast
会议
NanoparticlesCo-deliveryMicroRNA-34aDoxorubicinCombined therapy
Natural polymer-protein conjugates in oral vaccine formulations
Oral vaccines have potential advantages over injected ones to provide effective mucosal and systemic immunity due to their non-invasive nature,lower production costs,as well as higher practicality and
会议
模拟微重力体外构建组织工程神经的研究
应用含支持细胞的组织工程化神经修复长距离周围神经缺损己经成为一个研究热点。然而，在以往的研究中采用直接注射法存在支持细胞流失、细胞状态未知、归属难于把握等诸多不可控因素。
会议
周围神经组织工程体外构建生物反应器皮肤源性前体细胞
The Differential Cytotoxicity of Water-soluble Fullerene Derivatives by Improved Nitrene Chemistry
Water-solublefullerenes,C60[N(CH2)2OH]12,C60[N(CH2)2NH2]10,and C60[N(CH2)2COOH]10,were synthesized by improved nitrene chemistry[1],which C60 was reacted with azide small molecules(N3(CH2)2OH,N3(CH2)2
会议
Water-soluble Fullerene DerivativesNitrene ChemistryCytotoxicity
Nanopore-based tetracycline detection
rtTA(reverse tetracycline-controlled transactivator) and TRE(Tetracycline Responsive Element) will bind to each other under the action of tetracycline and form one complex.When this complex passes thr
会议
Preparation and Anti-Tumor Activity of mesoporous silica nanoparticles (MSN) containing both free an
Mesoporous silica nanoparticles(MSNs)are a promising material for drug delivery.We delicately prepared a mesoporous silica nanoparticle(MSN)for the delivery of low water solubility drug to tumor cells
会议
Ursolic acidmesoporous silica nanoparticleanti-tumor activity
Folate-functionalized redox-sensitive biodegradable micelles for improved intracellular delivery of
Despite the significant advantages of nano-micellar systems on drug delivery,the poor therapeutic outcome in clinic is ascribed to inefficient tumor uptake and poor intracellular drug release.Plumbagi
会议
MicellesPlumbaginDisulfide linkageFolate receptorBreast cancer cells