【摘 要】
：
本课题组借鉴"基因诊断治疗"策略,以中药谱效关系为切入点,建立基于目标组分敲出/敲入(component knock-out&knock-in)的中药谱效关系与量效关系研究模式,多快好省地确定中药药效关键物质(主要药效组分和/或药效相关组分).以金银花为例,采用此方法敲出了抗呼吸道合胞病毒关键药效组分3,5-O-咖啡酰奎尼酸,3,4-O-咖啡酰奎尼酸和4,5-O-咖啡酰奎尼酸,其中3,5-O-咖啡
【机 构】
：
解放军302医院,北京100039 解放军302医院,北京100039;成都中医药大学药学院,四川
论文部分内容阅读
本课题组借鉴"基因诊断治疗"策略,以中药谱效关系为切入点,建立基于目标组分敲出/敲入(component knock-out&knock-in)的中药谱效关系与量效关系研究模式,多快好省地确定中药药效关键物质(主要药效组分和/或药效相关组分).以金银花为例,采用此方法敲出了抗呼吸道合胞病毒关键药效组分3,5-O-咖啡酰奎尼酸,3,4-O-咖啡酰奎尼酸和4,5-O-咖啡酰奎尼酸,其中3,5-O-咖啡酰奎尼酸的抗病毒活性最强.目前,尚无治疗呼吸道合胞病毒很好的化学药和生物药.以利巴韦林为阳性药,3,5-O-咖啡酰查尼酸的抗病毒活性强,可能的作用机理是抑制病毒对细胞的吸附和穿入两个环节.敲除/敲入的物质筛查方法有望成为一种全新的药效组分筛查模式,具有重要的应用前景.
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