【摘 要】
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Objective:To test the hypothesis that a tentative integrative model by combining genetics, neuroendocrine and cognition biomarker could predict antidepressant response in depressed patients Method:A t
【机 构】
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Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (M
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Objective:To test the hypothesis that a tentative integrative model by combining genetics, neuroendocrine and cognition biomarker could predict antidepressant response in depressed patients Method:A total of 365 depressed patients, age 18-55 years, fulfilling the DSM-Ⅳ diagnostic criteria for major depressive disorder, with a minimum HAMD score at 18, were recruited for this study.All patients were randomly assigned into either the SSRI (N=290) or the TCA (N=75) group and received a 6-week period of treatment.Response was defined as a >50% of the reducing scores rate of HAMD scores at the end of the 6th week.Nine single nucleotide polymorphisms (SNPs) in two genes (BDNF, NTRK2) selected from dbSNP (http://www.ncbi.nlm.nih.gov) or previous literature were studied.Result:There were significant association between three SNPS (rs1221, rs716893, rs720141) and response to antidepressant treatment, but only SNP ofrs720141 remained significant after correcting for multiple testes using FDR method.Haplotype analysis revealed that the C-G haplotype of NTRK2 was associated with antidepressant treatment failure (p=0.029).MANOVA analysis showed that there was a significant difference in performance of WCST test between two groups (p<0.05).By using logistic regression, We found that a main effect on predicting treatment response was apparent for rs720141 genotype, the continuous errors number and the scores of negative events (p=0.001, OR=3.155, 95%CI=1.579-6.303; p=0.012, OR=0.967, 95%CI=0.943-0.993; p=0.017, OR-0.990, 95%CI=0.982-0.998, separately).The combination of the three factors revealed the 74.8% explanation for the variance.Conclusion: Combining rs720141 genotype in NTRK2 gene, the continuous errors number in WCST test and scores in negative life events, could be the best predictors for antidepressant response in depressed patients.
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