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  5. Combination Therapy for Ulcerative Colitis:Orally Targeted Nanoparticles Prevent Mucosal Damage and

Combination Therapy for Ulcerative Colitis:Orally Targeted Nanoparticles Prevent Mucosal Damage and

来源 :中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议 | 被引量 : 0次 | 上传用户：chenwu
【摘 要】
：
Combination therapy is an emerging strategy that is under intensive preclinical investigation for the treatment of various diseases(1).CD98 is highly overexpressed on the surfaces of epithelial cells
【作 者】
：
Bo Xiao Didier Merlin 
【机 构】
：
Institute for Clean Energy and Advanced Materials,Faculty of Materials and Energy,Southwest Universi
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
【发表日期】
：
2016年5期
【关键词】
：
oral administration combination therapy mucosal protection anti-inflammation tar 
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　　Combination therapy is an emerging strategy that is under intensive preclinical investigation for the treatment of various diseases(1).CD98 is highly overexpressed on the surfaces of epithelial cells and macrophages in the colon tissue with ulcerative colitis(UC),which is usually associated with mucosal damage and inflammation.We previously proved that CD98 siRNA(siCD98)-induced down-regulation of CD98 in colitis tissue decreased the severity of UC to a certain extent(2).In an effort to further improve the therapeutic efficacy,we aim to simultaneously deliver siCD98 in combination with a potent anti-inflammatory agent,curcumin(CUR),using hyaluronic acid(HA)-functionalized polymeric nanoparticles(NPs).
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