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目的 Thisstudyaimedtoidentifytheeffectofhome-basedlowerlimbstrengthtrainingtraininginpatientswithstablechronic obstructivepulmonarydisease(COPD).Wetriedtoprovidescientificevidenceforthedevelopmentofsimple,safeandfeasible home-basedlowerlimbstrengthtraininginterventionsforstableCOPDpatients. 方法(1)Home-basedlowerlimbstrengthtraininginclude：Sixsetsoflowerlimbtraining(including：straightlegliftingexercises, pronehipextensionexercises,thighabductionexercises,posteriormusclegroupexercises,priorandposteriormusclegroup exercises,standingcalfraise),usingthemethodofself-gravityresistanceandThera-bandresistance,8～12RM,20～30min/session, 3sessions/week,foradurationof12weeks.(2)Weconducteda12-weekrandomizedcontrolledtrial.Patientswhometour inclusioncriteriawererandomizedintotheinterventiongroup(n=25)andthecontrolgroup(n=22).Interventiongroupreceived routinepulmonaryrehabilitationguidanceandhome-basedlowerlimbstrengthtrainingwhilecontrolgroupreceivedroutine pulmonaryrehabilitationguidance.Bothgroupsreceivedscheduledtelephonevisits,andinterventiongrouphadadditional homevisitsifnecessary.Themusclestrength,fiverepetitionsit-to-standtest,six-minutewalkdistance,ModifiedMedical ResearchCouncildyspneascale,qualityoflifewerecomparedatenrollmentandat12weeks. 结果 1.Therewasnostatisticallysignificantdifferencebetweenthecontrolgroupandtheexperimentalgroupinbaselinedata(P＞ 0.05).2.Atweek12,comparedwithatbaseline,improvementsinallindexesofmusclestrength(isometricextensormusclepeak torgue,isometricextensormusclepeakTQ/BW,isokineticextensormusclepeaktorgue,extensormusclepeakTQ/BW)inthe interventiongroupyieldedstatisticalsignificance(P＜0.05).Improvementinisometricextensormusclepeaktorgueinthecontrol groupindicatedstatisticalsignificance(P=0.017),nosignificantdifferencewasobservedinotherindexesofmusclestrengthinthe controlgroup(P＞0.05)；Atweek12,decreaseinFTSSTintheinterventiongroupcomparedwiththatatenrollmentyielded statisticalsignificance(P=0.010).However,therewasnosignificantdifferenceinthecontrolgroup(P＞0.05)；Atweek12,intragroup comparisonshowedthatincreasein6WMDinbothgroupscomparedwiththatatenrollmentyieldedstatistical significance(P=0.014,P=0.018).3.Atweek12,therewasintra-groupeffectintheinterventiongrouponthedecreaseofmMRC(P=0.045)whiletherewasnosignificantdifferenceinthecontrolgroup(P＞0.05)；Atweek12,withininterventiongroup, comparedwithatenrollment,deceasesinCATtotalscores,coughscores,expectorationscores,chestdistressscores,feelingof climbinguphillorclimbingstairsscoresandconfidenceingoingoutsidescoresyieldedstatisticalsignificance(P＜0.05).No significantdifferencewasobservedintheotheritemsofCATintheinterventiongroup(P＞0.05).Inthecontrolgroup,therewas significantdeceaseinscoresofconfidenceingoingoutside(P=0.035).Nosignificantdifferencewasobservedintheotheritems ofCATinthecontrolgroup(P＞0.05)；Atweek12,intra-groupcomparisonshowedthat,comparedwithatenrollment,mean scoresofactivitiesofdailylivingandanxietyyieldedstatisticalsignificanceintheinterventiongroup(P＜0.05)aswellasinthe controlgroup(P＜0.05).Inaddition,comparedwithatenrollment,totalmeanscoreofCOPD_QoLwithinthecontrolgroup yieldedstatisticalsignificance(P＜0.05),nosignificantdifferencewasobservedintheotheritemsofCOPD_QoLinthecontrol group(P＞0.05). 结论 Inthisstudy,liketheroutinepulmonaryrehabilitationguidance,home-basedlowerlimbstrengthtrainingcanimporovethe musclestrength,exerciseendurance,confidenceingoingoutsidescores,activitiesofdailylivingandanxietystatus.Compared withroutinepulmonaryrehabilitationguidance,home-basedlowerlimbstrengthtrainingcanimprovethemusclestrength,lower limbfunctionandtheCOPDsymptoms(dyspneascore,coughscores,expectorationscores,chestdistressscores,feelingof climbinguphillorclimbingstairsscores)moreeffectively.Therefore,itisrecommendableforpatientswithstableCOPD.