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Deregulated myocardial fibrosis is a major cause of cardiac dysfunction.The focus of this investigation was to elucidate the importance of miRNAs in the control of pathophysiological processes following cardiac fibrosis.Gain of function and loss of function approaches in a specific miRNA transgenic mouse models were employed in the present study.First, we found that the level of the miRNA is aberrantly upregulated in the border zone of infarcted heart of wild type (WT) mouse following cardiac fibrosis by occlusion of the left coronary artery (LCA).