The X-linked gene cyclin-dependent kinase-like 5(CDKL5)is associated with severe neurodevelopmental diseases including Rett-like syndrome and early onset seizure.
Advanced maternal age mothers are become more and more at present,whether their offspring will normally develop and mature is a long-term controversial topic.
For nearly two decades,we recorded 14,045 and labeled 2,052 and reconstructed 1005 neurons constituting the microcircuit in all six neocortical layers of somatasensory cortex(SSC)of P14-P16 rats using
Retinal cell fate determination is modulated by both signaling molecules and transcriptional factors,however,the roles of microRNAs(miRNAs)in this network are far from clear.
Objective Radial glial cells(RGCs),the instructive scaffolds for neuronal migration,are well characterized by their unique morphology and polarization,with elongated basal processes extending to the p