Gadd45a is a heterochromatin relaxer that enhances iPS cell generation

来源 :第九届广州国际干细胞与再生医学论坛暨第五届中国再生细胞生物学年会 | 被引量 : 0次 | 上传用户：cynthializzu

【摘要】

：

Reprogramming of somatic cells to induced pluripotent stem cells rewrites the code of cell fate at the chromatin level.Yet,little is known about this process physically.

【作者】

：

Keshi Chen Xingguo Liu Duanqing Pei

【机构】

：

Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,China

【出处】

：

第九届广州国际干细胞与再生医学论坛暨第五届中国再生细胞生物学年会

【发表日期】

：

2016年5期

【关键词】

：

chromatin relaxer FRAP Gadd45a heterochromatin relaxation reprogramming

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Reprogramming of somatic cells to induced pluripotent stem cells rewrites the code of cell fate at the chromatin level.Yet,little is known about this process physically.

其他文献

Cell-matrix adhesion mediates the interaction between human pluripotent stem cell morphology and plu

It has been reported that the reprogramming efficiency of induced pluripotent stem cells(iPSCs)can be controlled by microenvironment.However,the relationship among microenvironment,cell morphology,and

会议

pluripotent stem cellscell-matrix adhesioncell morphology

PRC1 components mediate dual functions in transcriptional regulation via interacting with Oct4 or Na

Polycomb group(PcG)complex plays an important role in gene repression.The complex with different subunits exerts different function,while the exact component of certain complex are not clear.

会议

Polycomb groupOct4dual functions

The research of signal path in osteogenetic differentiation of human umbilical cord mesenchymal stem

It has been reported that human umbilical cord mesenchymal stem cells(hUCMSCs)have the potential to differentiate into osteoblasts.But until now,the molecular mechanism of hUCMSCs osteogenesis remain

会议

hUCMSCsosteogenesis1α25(OH)2VD3signal pathway

ALDH1B1 Links Alcohol Consumption and Diabetes

Aldehyde dehydrogenase 1B1(ALDH1B1)is a mitochondriai enzyme sharing 65%and 72%sequence identity with ALDH1A1 and ALDH2 proteins,respectively.Compared to the latter two ALDH isozymes,little is known a

会议

ALDH1B1stem cellalcoholdiabetes

Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and

Currently,the long-term survival of adult B-ALL patients is less than 50%.To improve the cure and survival rates of adults,there is an increasing need to understand the biology of B-ALL and to charact

会议

B-ALLleukemia stem cellheterogeneityxenografts

Novel insights into Parkinson's disease through iPSC-based technology

会议

GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibit

Available therapeutic options for advanced B cell precursor acute lymphoblastic leukemia(pre-B ALL)are limited.Many lead to neutropenia,leaving patients at risk of life-threatening infections and resu

会议

pre-B ALLGZD824SRCPI3K/AKTPDX

Interactome of Jmjd1a and Jmjd2c regulate pluripotency in embryonic stem cells

Jmjd1a and Jmjd2c are well-known epigenetic regulators that play significant role in stem cell identity through demethylating H3K9Me2 and H3K9Me3,respectively.

会议

Jmjd1aJmjd2cpluripotencyembryonic stem cellenhancer

Harmine,a natural product capable of in situ reprogramming

Harmine is a natural compound possessing insulin-sensitizing effect in db/db diabetic mice.However its effect on adipose tissue browning(reprogramming)is unknown.

会议

Obesitybrownings

Nanog Regulates the Pluripotency of ESCs through Distinct Pathways

To better understand how Nanog functions in regulating self-renewal and maintaining pluripotency,we report in this study our improved in vivo biotinylation approach for affinity purification of Nanog-

会议

NanogInteractomePluripotency

Gadd45a is a heterochromatin relaxer that enhances iPS cell generation

其他学术论文