The effect of Magnolol on the toll-like receptor 4/nuclear factor kappa B signaling pathway in Lipop

• 作 者: FUYunhe[1]ZHANGNaisheng[1]YANGZhengtao[1]LIUBo[1]FENGXiaoshen[2]LIFenyang[1]LIANGDejie[1]LIUZhicheng[1]LIDepeng[1]CAOYongguo[1]ZHANGXichen[1]
• 机 构: Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin
• 出 处: 中国畜牧兽医学会第三届中国兽医临床大会
• 发表日期: 2012年期

　　Magnolol,a hydroxylated biphenyl compound isolated from Magnolia officinalis has been reported to have anti-inflammatory properties.The purpose of this study was to evaluate the effect of magnolol on acute lung injury induced by lipopolysaccharide in mice.Male BALB/c mice were pretreated with dexamethasone or magnolol 1 h before intranasal instillation of LPS.7 h after LPS administration,the myeloperoxidase in lung tissues,lung wet/dry ratio and inflammatory cells in the bronchoalveolar lavage fluid (BALF) were determined.