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Kaposis sarcoma(KS)which is caused by Kaposis sarcoma-associated herpesvirus(KS-HV)infection,is a type of endothelial cell originated angioproliferative malignancy.Importantly,abundant angiogenesis is one of the most obvious features and important prerequisites of KS.Understanding the roles of KSHV in the induction of angiogenesis is definitely useful for understanding how KSHV infection drives the formation of KS tumors.