PKD inhibitor protects against LPS/D-GalN-induced acute liver injury in mice

• 作 者: DuanGuang-jie;ZhuJiang;XuCheng-yan;LiuYou-sheng;
• 机 构: Institute of Pathology, Southwest Hospital, Third Military Medical University, No.29, Gaotanyan Stre
• 出 处: 全军免疫学第七届学术交流会暨免疫学新进展主题论坛
• 发表日期: 2009年期

　　Background and Aim:Protein kinase D (PKD) is a newly described serine/threonine protein kinase that plays a pivotal role in inflammatory response.In the present study,the pathophysiological significance of PKD in the development of lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-Ga1N)-sensitized mice was investigated.Methods:The PKD inhibitor G(o)6976 was administrated into mice with LPS/D-Ga1N-induced acute liver injury.The degree of hepatic injury and inflammation was assessed subsequently.