纳米金表面化学调控肝癌细胞HepG2迁移侵袭依赖于Integrins介导的信号通路

来源 :2015中国力学大会 | 被引量 : 0次 | 上传用户：liongliong441

【摘要】

：

采用自组装技术在纳米金表面成功制备了不同的化学官能团,采用划痕损伤模型和Transwell小室测定不同表面化学的Au NPs对人肝癌细胞株HepG2细胞迁移和侵袭的影响;明确Au NPs表面化学调控肝癌细胞HepG2迁移侵袭依赖于Integrins介导的信号通路.研究结果有助于从新的角度评价NPs植入后的生物安全性,揭示NPs参与调控癌细胞迁移侵袭的生物力学机制.

【作者】

：

刘肖珩沈阳尹红梅洪锦勇

【机构】

：

四川大学华西基础医学与法医学院生物医学工程研究室,成都610041 四川大学华西药学院,成都610

【出处】

：

2015中国力学大会

【发表日期】

：

2015年2期

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