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The use of plants, plant extracts or plant-derived pure chemicals to treat disease is a therapeutic modality, which has stood the test of time.Indeed today many pharmacological classes of drugs include a natural product prototype.However, there is a revival of interest in using medicinal plants in their crude form (botanicals or standardized extracts) partly because botanicals are considered safer compared to pure compounds isolated from them.In an attempt to provide rational for the safer nature of botanicals, we observed the co-existence of CCBs and acetylcholinesterase inhibitors constituents in some plants with therapeutic potential in Alzboimers disease.Similarly, combination of CCBs with phosphodiesterase inhibitors (PDEIs) or anticholinergic constituents shown in some plants have the therapeutic potential in spasmodic and asthmatic conditions, where the inhibitory effect of CCBs on the heart is likely to offset the cardiac stimulation usually seen with PDEIs or anticholinergics.The co-existance of CCBs with cholinergics in herbs traditionally used in hypertension and/or constipation offers unique therapeutic potential, where both components are inhibitory in cardiovascular system acting through endothehum dependent and independent vasodiltaor effect (desirable in hypertension) but with opposing effects in other systems offering side-effects neutralizing potential.The antispasmodic component seen at high dose is likely to offset the abdominal cramps usually observed at high dose of gut stimulants used in constipation.Interesngly, the cholinergic activity was more evident in quiscent gut preparations, while antispasmodic (CCB) more evident in hyperactive preparations, which explains the medicinal use of herbs like ispaghol and ginger for their dual efficacy in constipation and diarrhoea, two oppositte disease states of the gut.The literature shows that Saw palmato used in prostate benign hyperplasia and St.Johns Wart in depression act through multiple pathways with effect enhancing potential.It appears as the presence of mutliple chemcials in botanicals not only neutralize each others side effects, but also the synergistic interaction in their natural form allows using lower doses resulting in lesser side effetcs.