Electrospun quercetin/cellulose acetate nanofibers fabricated using a Teflon-coated spinneret

• 作 者: Deng-GuangYu;
• 机 构: School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shangh
• 出 处: 2013年中国药物制剂大会——中国药学会药剂专业委员会2013年学术年会暨国际控释协会中国分会2013年学术年会
• 发表日期: 2013年期

　　The present study investigates the use of a Teflon-coated spinneret for fabrication of sustained-release electrospun nanofibers.Cellulose acetate (CA) and quercetin were used as filament-forming polymer and active pharmaceutical ingredient, respectively.The electrospinning was undertaken using both Teflon-coated spinneret and traditional stainless steel capillary as spinnerets.In field emission scanning electron microscopy images, the nanofibers produced using the Teflon-coated spinneret were of smaller diameter and narrower distribution (520 ± 80 nm) than equivalent nanofibers fabricated from stainless steel equivalent (780 ± 190 nm).In vitro dissolution tests revealed that sustained-release profiles of nanofibers from the Teflon-coated spinneret were superior to those of their stainless steel equivalents, although quercetin existed in a similar amorphous state in both nanofibers.Because the Teflon-coated material can exploit the electrical forces more effectively than its steel analogue, it can enhance the electrospinning technique for generating polymer-based functional nanofibers.