Novel 4-Arm-PEG-TPGS Amphiphilic Copolymer Micelles Loading Paclitaxel: Preparation, Characterizatio

• 作 者: YupeiWu;SongweiTan;XiangtingZhuang;YulingBao;TingtingWu;ZhipingZhang;
• 机 构: Tongji School of Phamarcy,Tongji Medical College,Huazhong University of Science & Technology,Wuhan 4
• 出 处: 2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
• 发表日期: 2014年期

　　Over the past few decades, the exploitation of branched PEG modified biocompatible and biodegradable polymers has received considerable attention.These polymers containing both hydrophobic and hydrophilic segments are of particular interest for biomedical applications, such as drug delivery.In this study, new amphiphilic block copolymers, 4-arm poly(ethylene glycol)-block-tocopheryl polyethylene glycol succinate (4-arm-PEG-C-C-TPGS、 4-arm-PEG-S-S-TPGS) with different molecular weight of 4-arm-PEG (5K、 10K、 20K) were synthesized to as potential paclitaxel (PTX) carriers.