The anti-apoptotic effect of hydrogen sulfide attenuates injuries to the medullary respiratory cente

• 作 者: LihongNie[1]YajieHu[2]XiangYan[2]MingqiangLi[2]LiChen[2]HuiLi[2]XiankeLi[2]HuaZhou[2]YuZheng[2]
• 机 构: Department of Physiology,West China School of Preclinical and Forensic Medicine,Sichuan University,C
• 出 处: 中国生理学会张锡钧基金第十三届全国青年优秀生理学学术论文交流会暨中国生理学会第十一届全国青年生理学工作者学术会议
• 发表日期: 2015年期

　　Noxious substances released from burning cigarettes may cause hypoxia, ischemia and neurotoxic effects that impede the development of the central nervous system, including brainstem respiratory centres.Our previous studies demonstrated that hydrogen sulphide (H2S) could protect medullary respiratory centres from the injuries caused by hypoxia in in vitro preparations from neonatal rats.The present experiments were carried out to study the protective effects of H2S, potentially mediated by an anti-apoptotic mechanism, against injury of the medullary respiratory centres induced by intrauterine cigarette smoke exposure.