【摘 要】
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Aim Esophageal squamous cell carcinoma(ESCC)is one of the most common malignant tumors.The oncogene c-MYC is thought to be important in the initiation,promotion,and therapy resistance of cancer.In the
【机 构】
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Gansu University of Traditional Chinese Medicine,Lanzhou,730000,China
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Aim Esophageal squamous cell carcinoma(ESCC)is one of the most common malignant tumors.The oncogene c-MYC is thought to be important in the initiation,promotion,and therapy resistance of cancer.In the present study,we aim to investigate the clinicopathologic roles of c-MYC in ESCC tissue.Methods: The present study is aimed at discovering and analyzing c-MYC expression in a series of human esophageal tissues.95 ESCC samples were analyzed by the WB and IHC techniques.Then,correlation of c-MYC expression with clinicopathological features of ESCC patients was statistically analyzed.Results In most ESCC cases,the c-MYC expression was positive in tumor tissues,The PR(positive rate)of c-MYC expression in tumor tissues was 61.05%(58/95),obviously higher than the adjacent normal tissues(ANT)(8.42%,8/92)and AHT(19.75%,16/95).Over-expression of the c-MYC was detected in 61.05%(58 of 95)ESCCs,which was significantly correlated with the degree of differentiation(P=0.004).The PR of c-MYC was 41.5%(17/41)in T1+T2 esophageal tissues,and 74.1%(40/54)in T3+T4 esophageal tissues,with a significantly statistical difference(P=0.001).The PR of c-MYC was 45.0%(18/40)in Ⅰ+Ⅱ esophageal tissues,and 72.2%(39/55)in Ⅲ+Ⅳ esophageal tissues,with a significantly statistical difference(P=0.011).The c-MYC expression strongly correlated with clinical staging(P=0.011),differentiation degree(P=0.004),lymph node metastasis(P=0.003)and invasion depth(P=0.001)of patients with ESCC.Conclusion: The c-MYC was differentially expressed in a series of human esophageal tissues,and the aberrant c-MYC expression could be a potential factor in carcinogenesis and progression of ESCC.There was a statistical signification for c-MYC in ESCC patients to analyze clinicopathological features.It possibly becomes a new diagnostic indicator of ESCC.
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