【摘 要】
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It is well documented across many areas of biological science that reproducibiiity of experiments among labs is challenging (Prinz,Schlange et al.2011,Begley and Ellis 2012).A number of factors contri
【机 构】
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Miami Project to Cure Paralysis, University of Miami, Miami, FL 33136, USA
【出 处】
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第三届国际神经再生高峰论坛暨第五届脊髓损伤治疗与临床试验国际交流会(INRS2013 & 5th ISCITT)
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It is well documented across many areas of biological science that reproducibiiity of experiments among labs is challenging (Prinz,Schlange et al.2011,Begley and Ellis 2012).A number of factors contribute to this problem; chief among them is the relatively poor documentation of experimental methods in many papers.Recent failures to replicate significant findings in the spinal cord injury field demonstrate a need for improved documentation of experimental metadata (Landis,Amaraefa/.2012,Steward,Popovich ef al.2012).In collaboration with a group of 35 U.S.and Japanese scientists,we have developed a draft standard for Minimal Information about a Spinal Cord Injury experiment (MIASCI).Guidelines developed by the Minimum Information for Biological and Biomedical Investigations (MIBBI) project (Taylor,Field ef al.2008) were used to develop the MIASCI.After the MIASCI was assembled,surveys were done to rank the importance of items in the MIASCI,as judged by domain experts.The MtASCI covers a wide range of topics such as animal housing,surgery conditions,treatments (drugs,RNAi,cell transplants,etc),histology,imaging,and behavioral testing.At present,the MIASCI has approximately 300 items in the checklist.We will present the preliminary results summarizing the draft MIASCI items.Further refinement will need additional input from the SCI community.The long-term goal is to produce a standard that is both comprehensive and concise so that authors,editors and reviewers can easily comply with the recommendations.The MIASCI will also greatly facilitate future data mining and knowledge discovery in the SCI domain.
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