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目的:观察大黄在急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)机械通气的肺保护作用。方法:对符合纳入标准100例ALI患者随机分为两组,对照组50例给予常规综合治疗,治疗组50例加用大黄鼻饲;比较两组呼吸力学、血流动力学及动脉血气的变化等指标的变化以及患者上机天数、住ICU时间及ICU病死率。结果:治疗组与对照组的呼吸力学、血流动力学及动脉血气的变化及上机天数、住ICU时间及ICU病死率比较差异有显著性。结论:大黄能改善患者的呼吸力学、血流动力学及动脉血气指标,降低MOF发生率,缩短ICU时间,疗效确切。
Objective: To observe the protective effect of rhubarb on lung injury induced by acute lung injury / acute respiratory distress syndrome (ALI / ARDS). Methods: A total of 100 patients with ALI who met the inclusion criteria were randomly divided into two groups. The control group of 50 patients were given conventional combined therapy and the treatment group of 50 patients with rhubarb nasal feeding. The changes of respiratory mechanics, hemodynamics and arterial blood gas were compared Indicators of changes and the number of patients on the machine, ICU live ICU and mortality. Results: The changes of respiratory mechanics, hemodynamics and arterial blood gas of the treatment group and the control group were significantly different from the days of operation, the time of ICU stay and the mortality of ICU. Conclusion: Rhubarb can improve the patient’s respiratory mechanics, hemodynamics and arterial blood gas index, reduce the incidence of MOF, shorten the ICU time, the exact effect.