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  5. Learning from nature: Peptidomimetic of Hp1404 and identification of K1K8 as an improved anti-infect

Learning from nature: Peptidomimetic of Hp1404 and identification of K1K8 as an improved anti-infect

来源 :第12届生物毒素研究及医药应用学术大会 | 被引量 : 0次 | 上传用户：aixiaowen
【摘 要】
：
As an alternative class of antimicrobial agent to overcome the drug resistant infections,antimicrobial peptides (AMPs) have gained significant attention.Here, we designed and got an improved antimicro
【作 者】
：
Zhongjie Li Gaomin Liu Lanxia Meng Xiaobo Xu Wenxin Li Yingliang Wu Zhijian Cao 
【机 构】
：
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, P R Chin
【出 处】
：
第12届生物毒素研究及医药应用学术大会
【发表日期】
：
2015年5期
【关键词】
：
Antimicrobial peptides Hemolysis Serum stability MRSA skin infection Resistance 
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　　As an alternative class of antimicrobial agent to overcome the drug resistant infections,antimicrobial peptides (AMPs) have gained significant attention.Here, we designed and got an improved antimicrobial peptide K1K8 based on the molecular template of Hp1404.Compared to the wild type Hp1404, K1K8 has an improved antibacterial spectra in vitro, a lower hemolytic activity,and an enhanced serum stability.
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