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In this talk I shall discuss semi-classical orthogonal polynomials arising from perturbations of classical weights.It is shown that the coefficients of the three-term recurrence relation satisfied by the polynomials can be expressed in terms of Wronskians which involve special functions.These Wronskians are related to special function solutions of the Painleve equations.Using this relationship recurrence relation coefficients can be explicitly written in terms of exact solutions of Painleve equations.