【摘 要】
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the glycosites and site-specific glycoforms of human liver tissues between HCC and adjacent normal tissues were well characterized,simultaneously.Totally,4491 site-specific glycoforms attached onto 78
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the glycosites and site-specific glycoforms of human liver tissues between HCC and adjacent normal tissues were well characterized,simultaneously.Totally,4491 site-specific glycoforms attached onto 786 glycosites could be quantified from the above two samples,including many significant changed glycosites and site-specific glycoforms.Additionally,this method was utilized to evaluate the aberrations of sialylated glycosylation between the HCC and healthy serum samples.And several significantly changed glycoforms attached onto immune proteins were obtained,and a small cohort study with 19 individual serum samples(10 HCC patients and 9 normal human volunteers)were performed using PRM based targeted analysis.Interestingly,several glycoforms were still obtained with the p-Value as low as 4.7X10-5.This platform provides a powerful tool for comprehensive analysis of glycosylation,which will have broad applications in glycoproteomics analysis.
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