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Background: Most renal cell carcinoma (RCC) occur in one kidney;however, in a small set of patients (0.7-4.7%), RCCs occur in both kidneys (bilateral RCC).This particular type of RCC poses a challenge for clinical treatment and management.Most bilateral RCCs are sporadic, and do not show a hereditary pattern indicative of Von Hippel-Lindau (VHL) syndrome or other inherited cancer.