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目的：制备胸腺肽微球，并研究其性质。方法：以邻苯二甲酸醋酸纤维素为成球材料，胸腺肽为球心物，制备工艺经均匀设计优化。结果：得到白色粉末状微球。微球载药量３１．２±１．４％。平均粒径１５．６ｍ。微球在ＨＭ胃液中２ｈ释药不超过１０％，在人工肠液中２ｈ释药１００％。微球给大鼠灌胃后，ＨＰＬＣ测得大鼠血中胸腺肽浓度在２～３ｈ最高。结论：制备的胸腺肽微球可口服吸收。
Objective: To prepare thymosin microspheres and study its properties. Methods: Using cellulose acetate phthalate as the material of the sphere and thymosin as the center of the sphere, the preparation process was optimized by uniform design. Results: White powdery microspheres were obtained. Microsphere drug loading 31.2 ± 1.4%. The average particle size of 15.6m. Microspheres in HM gastric juice 2h release of not more than 10% in artificial intestinal juice 2h release of 100%. After intragastric administration of microspheres to rats, the concentration of thymosin in rat blood was the highest at 2 ~ 3h after HPLC. Conclusion: The prepared thymosin microspheres can be taken orally.