【摘 要】
：
Tuberculosis is a worldwide health problem, as an increasing threat with the spread of HIV infection and drug resistant Mycobacterium tuberculosis strains.Isoniazid (INH) and rifampin (RFP) are the ba
【机 构】
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上海市交通大学医学院病原生物学教研室 200025
【出 处】
：
中华医学会2010’全国临床微生物及感染免疫学术研讨会
论文部分内容阅读
Tuberculosis is a worldwide health problem, as an increasing threat with the spread of HIV infection and drug resistant Mycobacterium tuberculosis strains.Isoniazid (INH) and rifampin (RFP) are the backbone of the standard regimen for treating tuberculosis(TB), and resistance to these drugs indicates a necessity for alteration of the standard regimen.Increasing prevalence of INH resistance, especially in high tuberculosis (TB) prevalent countries is worsening the burden of TB control programs.It is reported that rpoB gene was associated with rifampin resistance, and mutations in the 81bp rifampin resistance determining region(RRDR) induce resistance to rifampin(RFP).Whereas the molecular basis for isoniazid(INH) resistance in Mycobacteriwn tuberculosis is complex.Putative isoniazid resistance mutations have been identified in katG, ahpC, inhA, kasA, and ndh.However, resistance in Mycobacterium tuberculosis to isoniazid (INH) is most caused by mutations in the catalase-peroxi-dase gene (katG).
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