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Understanding the mechanisms underlying the formation of memories is a central goal for neuroscientists.Adaption of structural and functional plasticity is the neural basis of memory processes.Epigenetic regulation has emerged as important mechanism for synaptic plasticity and memory formation.Long non-coding RNA (lncRNA) has no protein-coding ability and can act as epigenetic regulators.The role of lncRNAs in CNS,especially in memory processes has not been well-investigated.Using contextual fear conditioning rat model, a custom-designed microarray was applied to examine the expression profile of mRNAs and lncRNAs of hippocampal CA1 region during memory formation.1898 mRNAs and 1445 lncRNAs were identified to be significantly differential expressed.Bioinformatics methods (e.g.GO analysis,Pathway analysis and Dynamic-GeneNet analysis) were used for further function analysis.The genome-wide alteration of lncRNAs expression indicates lncRNAs could be potential regulator for memory formation, which provided new idea for elucidating the epigenetic mechanism of memories.