Visualization of the Inflammatory Response During Neurovascular Damage:Communication Between Microve

• 作 者: Feng Han
• 机 构: Institute of Pharmacology and Toxicology,Zhejiang University,Hangzhou,Zhejiang,China
• 出 处: 2016年第一届中国微循环周(中国病理生理学会微循环专业委员会全体会议、世界中医药学会联合会气血专业委员会全体会议、中国
• 发表日期: 2016年5期

　　AIM: Encephalopathy is a pivotal complication of sepsis yet the pathophysiology remains unclear.METHODS AND RESULTS: We tested the hypothesis that cerebral leukocyte-endothelial cell adhesion and microvascular leak are dependent on purinergic P2RX7 signaling that engages a specific β2-integrin/adhesion molecule/chemokine cascade culiminating in cerebral microglial activation and migration,neurovascular damage and septic encephalopathy.