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The molecular mechanisms of organ size control and regulation remain as one of the major unsolved mysteries of development biology in which biologist have long been interested.Almost a decade ago, the discovery of the Hippo signaling pathway in Drosophila have shed some light on this puzzling issue.The Hippo signaling network is highly conserved in both invertebrates and vertebrate.The core of the signaling pathway is a functionally conserved kinase cascade leading from kinases Hippo and Warts to the transcription factor complex formed by the coactivator Yorkie and its major DNA-binding partner Scalloped.The roles for Yorkie-Scalloped are beyond growth to encompass specific cell-fate determination.The control of their activity is crucial for tissue growth and maintaining homeostasis.We are pursuing several lines of research to focus on the mechanisms of how their activities are regulated.Recently,we demonstrate that Taiman, a steroid hormone receptor coactivator, facilitates the activity of Yorkie.We find that Taiman physically interacts with Yorkie and positively regulates its activity.In this talk, I will present recent progress in this area.