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目的观察在腹膜透析液(PDS)中添加丹参酮ⅡA对腹膜透析(PD)患者腹膜水清除的影响。方法 78例置管3个月的PD患者随机均分为两组:试验组在PDS中添加丹参酮ⅡA注射液10mg/2L;对照组PDS中不加药。均行持续非卧床PD治疗。用药3周前后行标准腹膜平衡试验(PET)及Mini-PET。结果与PD前比较,试验组用药后总水清除、自由水清除、4-h尿素氮、肌酐MTAC值均较用药前明显升高(P<0.05),小孔水清除、葡萄糖D/D0均较用药前明显降低(P<0.05)。结论在PDS中添加丹参酮IIA可以增加PD患者腹膜小分子溶质转运,并增加腹膜自由水清除及总水清除,对腹膜高转运患者作用也很明显。
Objective To observe the effect of tanshinone ⅡA in peritoneal dialysis fluid (PDS) on peritoneal water clearance in peritoneal dialysis (PD) patients. Methods A total of 78 patients with PD undergoing catheterization for 3 months were randomly divided into two groups. The experimental group was given tanshinone Ⅱ A injection 10 mg / 2L in PDS, and no PDS in the control group. All patients underwent continuous ambulatory PD. Three weeks before and after treatment standard peritoneal balance test (PET) and Mini-PET. Results Compared with the pre-PD, the total water and the free water in the test group were significantly decreased (P <0.05), and the values of 4-h urea nitrogen and creatinine were significantly increased (P <0.05) Compared with before treatment was significantly reduced (P <0.05). Conclusion The addition of tanshinone IIA in PDS can increase the peritoneal solute transport in peritoneum of patients with PD and increase the clearance of free water peritoneum and total water clearance, which is also obvious for patients with high peritoneal transit.