Genome-wide association study identified a chaperone of heat shock protein regulating carotenoid bio

来源 :第一届全国玉米生物学学术研讨会 | 被引量 : 0次 | 上传用户:xy59573928
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Carotenoids are natural pigments which play an important role in human health.To dissect the genetic basis of maize carotenoid biosynthesis and accumulation,a genome-wide association study was performed using 1.06 million SNPs and seven carotenoid related traits in a maize panel of 508 maize inbred lines.We identified 18loci significantly associated with carotenoid related traits in maize kernels at P <1.8E-6,and over half of the detected loci had the evidence support of QTL (11/18)and eQTL (13/18).Among these loci,a chaperone of heat shock protein,ZmTIM15,was significantly associated with the ratio trait in carotenoid biosynthesis pathway with P value of 2.45E-10.The function of ZmTIM15 was further validated by candidate-gene association mapping,linkage and expression analysis.These results provide useful insight into the genetic mechanism of carotenoid biosynthesis in maize kernels and biofortification of maize carotenoid related trait.
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