Biomimetic Total Synthesis of Paeoveitol

来源 :中国化学会第十三届全国有机合成化学学术研讨会 | 被引量 : 0次 | 上传用户：yukeno1

【摘要】

：

　　Paeoveitol,a pair of norditerpene enantiomers,were isolated by Chen from the root of Paeonia veitchii (Chuan-Chi-Shao),which has a long history of using as

【作者】

：

Zhang Yuhan Xie Zhixiang

【机构】

：

StateKeyLaboratoryofAppliedOrganicChemistry&CollegeofChemistryandChemicalEngineering,LanzhouUniversi

【出处】

：

中国化学会第十三届全国有机合成化学学术研讨会

【发表日期】

：

2016年10期

【关键词】

：

biomimetic synthesis hetero-Diels-Alder reaction paeoveitol D paeoveitol

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　　Paeoveitol,a pair of norditerpene enantiomers,were isolated by Chen from the root of Paeonia veitchii (Chuan-Chi-Shao),which has a long history of using as the composition in many traditional medicine formulas for the treatment of depression-like disorders in China.1 The challenging structural features and uncharacterized bioactivity of paeoveitol makes this compound an unusually appealing synthetic target.Zhao demonstrated elegant synthetic strategy that applied an unusual intermolecular ortho-quinone methide[4 + 2]-cycloaddition reaction for the synthesis of the paeoveitol.

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