【摘 要】
：
前期的临床研究发现,补肾益髓胶囊(原称二黄胶囊)是治疗多发性硬化(multiple sclerosis,MS)的有效方剂,但其对MS早期出现的轴突损伤和修复是否有作用还不清楚.本实验采用皮下
【机 构】
：
首都医科大学中医药学院,北京100069首都医科大学附属北京天坛医院,北京100050
【出 处】
：
首都医科大学第二届北京中医药研究生学术论坛
论文部分内容阅读
前期的临床研究发现,补肾益髓胶囊(原称二黄胶囊)是治疗多发性硬化(multiple sclerosis,MS)的有效方剂,但其对MS早期出现的轴突损伤和修复是否有作用还不清楚.本实验采用皮下背部注射髓鞘少突胶质细胞糖蛋白(myelin oligodendrocyte glycoprotein,MOG)35-55免疫C57BL/6小鼠,制备实验性自身免疫性脑脊髓炎(experimental autoimmune encephalomyelitis,EAE)-即MS模型,并给予补肾益髓胶囊灌胃治疗40d.结果显示补肾益髓胶囊能有效地改善EAE小鼠的临床症状和神经功能,减少发病率及死亡率,延长潜伏期,缩短病程的趋势,减轻髓鞘和轴突的损伤,且能减少脑和脊髓组织中急性轴突损伤的特异性指标淀粉样前体蛋白和神经再生的标志物微管相关蛋白2的表达.提示补肾益髓胶囊防治EAE的作用机制可能与减轻轴突损害和促进其再生修复有关.
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