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RATIONALE: Limonin and obacunone are two major limonoids distributed in the Rutaeeae and Meliaceae families.Their defined anti-tumor activity is closely connected with the furan ring and the multi-carbonyls in their structures.In vivo nd in vitro biotransformations may influence their structures and further change their effects.The metabolic profiles of limonin and obacunone have not been studied previously.In order to clarify their in vivo and in vitro metabolism, a comparative investigation of their metabolic pathways in five different species of liver microsomes and zebrafish was carried out.