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Prospective Study on the Treatment of Hyperpigmented skin graft by Intense Pulsed Light Narupon Rojanapithayakorn, MD, Tara Vongviriyangkoon, MD Division of Plastic Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok ,Thailand.Background and Objectives:Skin graft hyperpigmentation is a common phenomenon among Asian.This condition is difficult to treat and can cause severe psychological distress.Intense pulsed light (IPL) has been used to treat pigmented lesions with promising result.The role of IPL in treating skin graft hyperpigmentation has not been explored.The purpose of this study was to assess the efficacy and complication of IPL in the treatment of skin graft hyperpigmentation.Materials and Methods: 18 patients with Skin graft? hyperpigmentation were treated by IPL.There were 10 females and 8 males.Their age ranged from 21 to 70 years with a mean age of 49.6 years.The cutoff filters of 590 nm were used for 3 treatments at intervals of 3-4weeks.Patients were treated with an energy fluence of 20-28 J/cm2, pulse width of 2-4 milliseconds, double pulsemode, and a delay of 15-40 milliseconds.The degree of pigmentation (melanin index) was objectively recorded with a Derma Spectrometer.Subjective assessment was made by two blinded, nontreating physicians.Results: 11% of patients showed marked clinical improvement , 50% did moderate improvement, and 28% did slight improvement.The melanin index (37.56 ± 2.99) decreased after the treatment comparing before the treatment (40.67 ± 2.70), which shows a significant difference (P < 0.001).6 patients developed blisters and 3 patient had erythema that all resolved within 1 week without leaving permanent marks.Conclusions:IPL is effective and safe in treating skin graft hyperpigmentation.Adverse reactions were minimal and self-limited.