【摘 要】
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Abstract:Carbon monoxide(CO)poisoning causes the major injury and death due to poisoning worldwide.The most severe damage via CO poisoning is brain injury and mortality.Delayed encephalophathy after a
【机 构】
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Research Center of Occupational Medicine,Peking University Third Hospital,Beijing,100191,China
【出 处】
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中华预防医学会自由基预防学专业委员会2014年学术交流会议
论文部分内容阅读
Abstract:Carbon monoxide(CO)poisoning causes the major injury and death due to poisoning worldwide.The most severe damage via CO poisoning is brain injury and mortality.Delayed encephalophathy after acute CO poisoning(DEACMP)occurs in forty percent of the survivors of acute CO exposure.But the pathological cause for DEACMP is not well understood.And the corresponding therapy is not well developed.In order to investigate the effects of salvianolic acid(SA)on brain injury caused by CO exposure from the point view of hemorheology,we employed a rat model and studied the dynamic of blood changes in the hemorheological and coagulative properties over acute CO-exposure.Compared with the groups of CO and 20%manniol + CO treatments,the severe hippocampal injury caused by acute CO exposure was prevented by SA treatment.These protective effects were associated with the retaining level of hematocrit(Hct),plasma viscosity,fibrinogen,whole blood viscosities,malondialdehyde(MDA)levels in red blood cells(RBCs).These results indicated SA treatment could significantly improve the deformation of erythrocytes and prevent the damage caused by CO poisoning.Meanwhile,hemorheological index are good indicators for monitoring the pathological dynamic after acute CO poisoning.
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