【摘 要】
：
We compared the different biological processes and occurrence numbers of gene ontology (GO) in high expression (fold change≥2) activated amelogenin Y-linked (AMELY) non-regulation network of human hep
【机 构】
：
Biomedical Center, School of Electronic Engineering,Beijing University of Posts and Telecommunicatio
论文部分内容阅读
We compared the different biological processes and occurrence numbers of gene ontology (GO) in high expression (fold change≥2) activated amelogenin Y-linked (AMELY) non-regulation network of human hepatocellular carcinoma (HCC) and the corresponding low expression activated network of no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection).The biological processes in HCC contained actin filament-based movement, adhesion to symbiont, binding of host cell surface coreceptor, calcium-dependent cell-cell adhesion, cell cycle checkpoint, cytokinesis, DNA damage induced protein phosphorylation, endothelial cell migration, establishment of chromosome localization, induction of apoptosis, intracellular signaling cascade, keratinocyte proliferation, localization within membrane, low density lipoprotein mediated signaling, nucleocytoplasmic transport, protein complex localization,Rac protein signal transduction, Rho protein signal transduction, spindle checkpoint,sprouting angiogenesis, susceptibility to natural killer cell mediated cytotoxicity, viral envelope fusion with host membrane, virion attachment.We proposed and constructed a model of activated AMELY coupling downstream low density, Rac and Rho signal and nucleocytoplasmic transport to cytokinesis, spindle checkpoint and DNA damage protein phosphorylation-induced keratinocyte proliferation network including BIRC5, MAP2K6,CAMK1, CDH13 from activated GO-molecular network of HCC in GEO data set by gene regulatory network inference method and our programming.Our hypothesis was verified by the corresponding activated up-/down-stream network of HCC and inhibited network of no-tumor hepatitis/cirrhotic tissues, no result compared with activated network of no-tumor hepatitis/cirrhotic tissues and inhibited network of HCC.
其他文献
Objective Involvement of gray matter in the pathology of subcortical stroke was already recognized in animal studies.But the detection of cortical gray matter structure changes under modem magnetic re
There have been many attempts in cancer clinical-type classification by using a dataset from a number of molecular layers of biological system.Despite these efforts, however, it still remains difficul
We analyzed the different biological processes and occurrence numbers between low expression inhibited PTHLH downstream network-mediated aging gene ontology (GO) network of no-tumor hepatitis/cirrhoti
There is an increasing interest in using single nucleotide polymorphism (SNP) genotyping arrays for profiling chromosomal rearrangements in tumors, as they allow simultaneous detection of copy number
T-cell acute lymphoblastic leukemia (T-ALL) is anaggressive hematological malignancy.The under-standing of its gene expression regulation and mo-lecular mechanisms still remains elusive.Started from e
The ranking of ligand docking poses according to certain scoring systems to identify the best fit is the most important step in virtual database screening for drug discovery.By focusing on method deve
在当今的生物信息学领域，各种新技术不断推陈出新，大量的分析工具也随之快速涌现。在这些为数众多的工具当中，工作流平台虽然不具备特定的分析功能，但却日益成为研究工作中不可或缺的一部分，其在整合分析资源，固化工作成果，定制个性分析和提升工作效率等方面发挥了越来越重要的作用。
Neonatal sepsis (NS), a common disorder for human, is recognized as a leading global public health challenge.A meta-analysis was performed to assess the accuracy of the Serum amyloid A (SAA) test for
Many RNA editing factors are low-abundant transcripts in higher plant organelles.Modern transcriptomic sequencing (RNA-Seq) provides a powerful method to detect the glimmering expression of these gene