美沙酮维持治疗患者合并美金刚治疗效果分析

来源 :第四届中国酒精与药物滥用研讨会、第三届亚太酒精与成瘾学会会议 | 被引量 : 0次 | 上传用户:vc__
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背景:炎症细胞因子的激活可能与阿片类物质依赖的形成有关.本研究中,我们评估炎症因素是否与阿片物质成瘾有关.并进一步研究低剂量美金刚合并抗炎药对接受美沙酮维持治疗的海洛因依赖者的效果.方法:采用12周的双盲、随机、对照试验.定期接受美沙酮维持治疗的患者被随机分为:美金刚组(5mg/天)(n=50)或安慰剂组(n=75).在第0、1、4、8和12周检测美沙酮剂量需求和血浆细胞因子.结果:经过12周的治疗,相比安慰剂组,接受美金刚治疗的患者对美沙酮需求剂量显著降低.美金刚治疗组患者的血浆肿瘤坏死因子α (TNF-α)比对照组也显著减少.
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