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It is very important to understand why alkaliphiles could survive from alkaline environment,which is still poorly understood yet.Alkalimonas amylolytica N10 is such a kind of alkaliphilic bacteria found in China,which could survive from pH 7.5 to 11.0.Till now,only limited numbers of proteins were found in alkaliphiles,which are involved in regulation of pH homeostasis and play important roles in the adaptive mechanism.