【摘 要】
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The Help Cure Muscular Dystrophy (HCMD) project investigates protein-protein interactions for more than 2,200 human proteins whose structures are known,with
【机 构】
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UniversitePierreetMarieCurie,France
【出 处】
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The XXIX International Colloquium on Group-Theoretical Metho
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The Help Cure Muscular Dystrophy (HCMD) project investigates protein-protein interactions for more than 2,200 human proteins whose structures are known,with particular focus on those proteins that play a role in neuromuscular diseases.It screens each protein,predicts functional sites involved in binding to other proteins or ligand targets,and determines whether two proteins are potential interacting partners in the cell.The project will determine information on the structure of macromolecular complexes which is important not only for identifying functionally important partners,but also for determining how such interactions will be perturbed by natural or engineered site mutations in either of the interacting partners,or as the result of exogenous molecules,and,notably,pharmacophores.A database of such information would be of significant medical interest since,while it now becomes feasible to design a small molecule to inhibit or enhance the binding of a given macromolecule to a given partner,it is much more difficult to know how the same small molecule could directly or indirectly influence other existing interactions.HCMD is currently running its Phase 2 in World Community Grid (launch in may 2009).Phase 1 ended in June 2007 and the computation lasted about a year.I shall present some of the results coming from the analysis of the first phase of the project.
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