RNA HELICASE A, A TRANSCRIPTIONAL REGULATOR IS CRITICAL FOR DNA VIRUS-INDUCED INNATE IMMUNE RESPONSE

• 作 者: Yee Ching Ng Hye-ri Kang Hye-Jeong Cho Moon Jung Song
• 机 构: CollegeofLifeSciencesandBiotechnology,KoreaUniversity,Seoul,RepublicofKorea
• 出 处: 17th International Workshop on Kaposi’s Sarcoma Associated H
• 发表日期: 2014年7期

RNA helicase A (RHA) or known as aspartate-glutamate-alanine-histidine (DExD/H)-box helicase 9 (DHX9) has been extensively characterized as a transcriptional regulator, consistent with its mostly nuclear localization in various cell types.Recently, RHA/DHX9 was reported to act as a cytosolic B-form DNA sensor in plasmacytoid dendritic cells.In this study, we investigated the role of RHA/DHX9 on a DNA virus, murine gammaherpesvirus 68 (MHV-68) infection in fibroblast and epithelial cells.