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Polypeptide drugs cause increasing attention due to their application in clinical treatment.On the one hand, many linear peptides have good stability and biological activity in vitro, they degradate rapidly in vivo.On the other hand, cyclopeptide molecules possess relatively stable conformations.The sensitivity of cyclopeptide to aminopeptidase and carboxypeptidase decrease because there are no dissociative amino and carboxyl groups.That is, the metabolic stability and biological availability of cyclopeptide are much better than those of linear peptide.Thus, the research hotspot has been transferred to synthesis and evaluation of cyclopeptide molecules recently.In this work, we build a series of cyclopeptide molecules (from cyclic tripepfide to nonapeptide) using alanine as the structural units.