论文部分内容阅读
Chronic obstructive pulmonary disease are common destructive inflammatory diseases that are leading causes of death worldwide.Tobacco smoking induces an inflammatory response in the lungs of all smokers but,for reasons that are still poorly understood,only a proportion of them develop chronic obstructive pulmonary disease (COPD).Recent evidence indicates that emphysema is an autoimmune disease characterized by the presence of T-helper type 1 (TH1) responses,which correlate with emphysema severity,suggesting some type of auto-perpetuation mechanism similar to that described in autoimmune disorders.Regulatory CD4+T-cells expressing CD25 (Tregs) have been implicated in the pathogenesis of both COPD and several autoimmune processes,but their potential role in COPD has not been explored.The present study sought to evaluate CD4+T-cells expressing CD25 (Tregs) T-lymphocytes abnormalities in COPD.