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A novel noncovalent strategy to constructchemically synthesized glycopeptidevaccines has been designed toinduce a robust immune response and to dramatically improve the efficiency of vaccine preparation.GlycosylatedMUC1 tripartite vaccines were constructed through host–guest interactions with cucurbit[8]uril.These vaccines could elicit high levels of IgG antibodies that were recognizedby cancer cells and induced the secretion of cytokines.The antisera also could mediate complement‐dependentcytotoxicity.This noncovalent strategy with good suitability,scalability,and feasibility can be applied as a novelstrategy for the construction of chemically synthesizedvaccines.