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Objective: To characterize a Chinese DFNA22 family associated with a novel MYO6 mutation and to confirm the proposed genotype-phenotype correlation of MYO6.Methodology: Mutation screening of 79 deafness genes was performed in the proband by targeted next-generation sequencing.Co-segregation of the disease phenotype and the detected variants was confirmed in all family members by PCR amplification and Sanger sequencing.